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The Community Engagement Program’s CommunityAcademic Research Engagement (CARE) Committee prepared this guide to inform UCSF investigators about the processes and steps involved in developing research collaborations with community-based organizations and institutions. We have included resources to facilitate this work and address some of thebarriers to collaboration. The overall aim of this doc-ument is to orient UCSF researchers seeking to do rigorous research built on research partnerships with public and community-based agency staff. This guide is designed to inform, facilitate and support such partnerships so research can meet the needs of researchers, collaborative partners and participants. A companion guide is available on the UCSFCE website for agency staff who would like to explore such partnerships with UCSF investigators. While this document refers to specific UCSF resources and projects, much of the information it provides is generalizable to other institutions and can be a resource for investigators across the U.S.